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How CBD Absorption Is Affected By Fat-Rich Food?

Can you believe that you can actually have a cheesy burrito while you are under medication for weight loss? Yes, you heard it right. Now you can eat all your favorite delicious dishes without any restrictions deemed by your prescribed diet. But the catch is, the medication must be that of cannabinoids (CBD).

CBD, also called cannabidiol, is a compound present in the cannabis plant. This compound is known to be the powerhouse of the cures for many health problems. Unlike THC – the “high” causing element of cannabis, CBD does not produce such ‘effects’ but instead evokes a soothing comfort commonly associated with that of cannabis. In laymen terms, CBD is non-euphoric.

Many health enthusiasts consume CBD alongside their vitamin intakes on a daily basis to promote a healthy body. In fact, CBD is reportedly one of the most reputed medicinal substances derived from cannabis that is available in the market nowadays.

Despite the fact that cannabidiol has been recently approved by the FDA for medical purposes, there has been very little study about how different food habits affect the absorption of this cannabis derivative. Since its compliance in 2018, the oral cannabidiol capsules can be now used by patients suffering from seizures too.

A new study suggests that fatty foods might boost the body’s absorption of cannabidiol. In this study, the University of Minnesota researchers examined the effects of fatty foods and fasting on CBD absorption.


In the study conducted by the University of Minnesota:

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

it was examined whether consuming fast foods or high-calorie meals after taking CBD boosted the body’s absorption of it or not. The study also tested what type of effect does fasting or a high-fat content meal has when cannabidiol capsules are taken by the patients orally.

To know what effect does a fatty meal would have on CBD absorption, the research group measured CBD concentrations in the patients suffering from epilepsy. The investigators compared CBD concentrations in epilepsy patients who were taking 99 percent pure CBD capsules after they fasted and after they had a high-fat breakfast (such as a burrito).


  • The exposure of CBD increases drastically when it is consumed with high fatty foods.
  • When compared to fasting, if CBD is taken along with or before food, it quadruples in amount and effect. The maximum increase in amount recorded in the participants’ blood was 14-times
  • No cognitive differences were identified and were consistent with the previous studies
  • There were no changes in psychological functioning when the patients took CBD after eating or fasting
  • The increased levels of absorption were not connected to any differences in psychoactive or cognitive effects
  • The study does hypothesize an improved effect of CBD on seizure control if consumed with a high-fat meal.


The researchers opined that due to a large number of inconsistencies found while measuring the dose of the liquid formulation, capsule consumption allows more accurate delivery to the gut and also with more consistent absorption. This, in turn, provides more accurate blood level data for the purposes of studies associated with dosages, such as this.

According to Angela Birnbaum, a professor in the College of pharmacy and the co-author of the study, “the type of food that is consumed can make a large difference in the amount of CBD that gets absorbed into the body. Although fatty foods can increase the absorption of CBD, it can also increase the variability as not all meals contain the same amount of fat.”

Ilo Leppik, study co-author, a professor in the College of Pharmacy and an adjunct professor at the Medical School was of the view that “ an increase in the amount of the CBD dose being absorbed into the body can also lead to lower medication costs.”

It is been advised to all epilepsy patients to always ensure consistent blood concentrations of the drug. In accordance with the study, the CBD concentrations can vary significantly if patients take them differently or based on their own preferences, either with or without food. Variations in blood concentrations can become the leading cause for a patient to be more susceptible to seizures. A simple solution is to take CBD in an oil form to aid absorption.


There are limitations to the conclusion that has been devised from this study. But, one question that still remains unanswered is whether an equally calorie-rich food, but lower in fat, influences the absorption of CBD in the same way or not.

Another serious speculation that arises is that the study has been conducted on a very small sample. It has been experimented with only eight adults. The study so far is too underpowered to come to a conclusion but it is in line with the market availability of CBD infusions in oil. It also fails to examine whether certain meal conditions actively improve the seizure prevention aspects of CBD but eating healthy oils such as olive, coconut etc. can’t hurt.

By ignoring the flaws, the researchers have tried their best and they have been successful in providing reasonably conclusive recommendations. It also suggests that further studies on CBD must account for the overlooked food effects. Since all meals do not offer consistent concentrations of fat, the most important observation is that CBD is preferably better to be consumed with some kind of food or oil at the same time every day. Trying 30 days of an organic-oil infused CBD such as Ezra’s is worth it to assess whether it helps balance and regulate anxiety, jitters, or spasms.

As CBD is ascending to become a potential tool in addressing many  problems or ailments of the modern world such as anxiety, stress, aging, hormone imbalance, pain, and sleep, it may soon establish supremacy over other medicines to be the most versatile healing component in one’s medicine or supplement cabinet. CBD is revolutionizing the way people think about healthcare, skincare, and now food. CBD can interact with certain pharmaceuticals, therefore it is recommended to consult your doctor before taking CBD with food. Once, this point is clear, go ahead and enjoy your greasy burrito or alfredo with that CBD infused product! If you want help while you take a quality oil-infused CBD oil, start here and ask Ezra for help.

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