If you have found that your dose of medical marijuana is no longer having a strong effect on your symptoms then you may find yourself in a similar situation as those having to take more and more narcotics in order to reduce symptoms such as pain. This should not be the goal of marijuana. If your symptoms enable you to do so, it is recommended to either switch to a new strain to update your tolerance, or take a break for medicating for a few days to a week every few months. You may have some withdrawal symptoms such as irritability but they tend to be less than with over the counter narcotics. The benefit is you will decrease your tolerance, allowing the medicine to reduce symptoms when you start medicating again, and you will allow the body to recalibrate its own healing potential.